Yes, there is a difference in front brake rotors between those Escapes/Mariners/Tributes that have 4 wheel disc brakes and those with front disc and rear drums. Those with 4 wheel disc brakes have an 11.92" diameter front brake rotor (it is also roughly 0.10" thicker) while those with front disc/rear drum have a 10.94" diameter front rotor.
While on the subject of brakes, I have rear disc brakes on my Escape and I have yet to replace them, and I'm at 125k miles. I've disassembled them twice; removed the pads, clean the slides, lubricate everything. The pads are making good contact with the rotor but still look new. I have replaced the front brakes 3 times since I bought the truck at 55,000 miles. I'm pretty hard on my brakes. Did they not get the brake proportioning dialed in right on the '05-'06 Escapes with the rear disc brake option?