The spare won't work, and you may not be able to get one that does depending on the year of your Escape. 2001-2004 Escapes will not be able to fit any 29.88" spare tire. You should be able to fit a full-size under a 2005+ Escape, and I would just get a used tire on steel wheels instead of trying to find a compact spare. If you have one of the earlier models, you can get a can of tire sealant and carry a 12-V compressor, or you can get a roadside assistance plan.
By the way, no Escape has ever had a 4WD system. They market it in such, but the Escape, like most small SUVs, has an AWD system much like you would find in a sedan. No transfer case, no low-range, no locked 4x4 (not even the early Control-Trac II systems, the switch is another "trick"), and no 2WD-only mode. Notable exceptions are the Jeep Liberty and Nissan X-Terra.